WebJul 26, 2024 · FLT3(FMS-like tyrosine kinase-3)即FMS样酪氨酸激酶,是RTK家族的成员,其蛋白产物为细胞受体,其结构由胞外区、跨膜区和胞内区三部分组成。 胞外区的5个IgG样结构,是FLT3受体与配体的结合域,跨膜区是激酶不连续作用域,胞内区为酪氨酸激酶的催化区域。 正常情况下,受体酪氨酸激酶的近膜区(JM)和结构域(TKD)具有自我 … WebMar 31, 2024 · Chk1 has been reported to be a promising target for treatment of FLT3-ITD AML [ 25]. Therefore, we next investigated whether ATRA has any effect on the Chk1 protein in FLT3-ITD cells. Firstly we tested the effect of ATRA on Chk1 at different time points. These results show that Chk1 levels start to decrease on treatment with ATRA for …
聚焦药靶:挑战恶性血癌,靶向FLT3药物的最新进展 酪氨酸激酶
WebFrequently mutated in Acute myeloid leukemia (AML), FLT3 is considered as one of the favorable targets for treatment. The FLT3 internal tandem duplication (ITD) mutation enhances kinase... WebNov 29, 2024 · Home Cell Cycle Chk inhibitor AZD7762 AZD7762 Catalog No.S1532 For research use only. AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1. CAS No. 860352-01-8 Selleck's AZD7762 has been cited by … north american switchgear
CHK1 inhibitor CHK1 Selective inhibitors CHK1 isoform
WebOct 19, 2024 · Since RAD51 and CHK1 are regulated by mutant FLT3 (Bagrintseva et al. 2005; Kurosu et al. 2013) and by the cell cycle (Nikolova et al. 2024), we additionally … WebMar 1, 2007 · FLT3 and the DNA repair-related proteins, Chk1 and Rad51, were studied in small interfering RNA (siRNA)–induced cell growth inhibition experiments in human leukemia cells with wild-type or mutated FLT3. Results: We found that etoposide and the Hsp90/FLT3 inhibitor 17-AAG, had synergistic inhibitory effects on FLT3 + MLL-fusion gene leukemia … WebMar 29, 2024 · Checkpoint kinase 1 inhibitors (CHK1i) have shown impressive single-agent efficacy in treatment of certain tumors, as monotherapy or potentiators of chemotherapy … north american t-39a sabreliner