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Cisplatin mitophagy

WebMar 12, 2024 · The results have indicated that co-administration of melatonin and sorafenib induced an early mitophagic response in Hep3B cells and the status of mitochondrial membrane depolarization as a marker... WebOct 5, 2024 · Mitophagy refers to the selective self-elimination of mitochondria under damaged or certain developmental conditions. As an important regulatory mechanism to remove damaged mitochondria and maintain the internal and external cellular balance, mitophagy plays pivotal roles in carcinogenesis and progression as well as treatment. …

The cardioprotective effect of human glucagon-like peptide-1 …

WebMar 28, 2024 · Although mitophagy is considered of particular importance in protecting against AKI, little is known of the precise role of mitophagy and its molecular mechanisms during cisplatin-induced nephrotoxicity. Also, evidence that activation of mitophagy improved mitochondrial function is lacking. WebDec 31, 2024 · Since metformin is used as adjuvant drug to increase the efficacy of cisplatin-based neoadjuvant chemotherapy, we co-treated tumour cells with micromolar doses of metformin in the presence of cisplatin observing a marked reduction of MAP1LC3B-II and an increase of caspase 3 cleavage. ... Mitophagy, as assessed by … csu wildflecken https://michaeljtwigg.com

PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney ... - PubMed

WebThe synergistic effect of cisplatin and the DRP1 inhibitor on HCC was assessed in vitro and in vivo. Accordingly, cisplatin induced mitophagy in surviving HCC cells by activating DRP1. The DRP1 inhibitor (Mdivi‑1) increased the apoptosis of cisplatin‑treated HCC cells by targeting mitophagy. WebThe role of autophagy/mitophagy was investigated by transient transfection of siATG14, GFP-LC3, tF-LC3, mKeima-Red-Mito7 and Western blot analysis of autophagic and mitochondrial proteins. Results: In vitro and OSCC tissue double labelling confirmed that CD44+cells co-expresses ABCB1 and ADAM17. WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. ... Cisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and ... csu wildlife society

Berberine alleviates cisplatin-induced acute kidney injury by ...

Category:Apurinic endonuclease 1 promotes the cisplatin resistance of lung ...

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Cisplatin mitophagy

Berberine alleviates cisplatin-induced acute kidney injury by ...

WebJan 13, 2024 · Abstract. Cisplatin is an efficacious anticancer agent, but its use is limited by ototoxicity and resultant irreversible sensorineural hearing loss. … WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice.

Cisplatin mitophagy

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WebOct 7, 2024 · Chaetomugilin J Inhibits Mitophagy Induced by Cisplatin. Mitophagy is a type of autophagy that eliminates redundant or damaged mitochondria. 26 It plays an important role in mitochondrial function. The expression of pink1 and parkin, which are mitophagy-related proteins, were detected to reflect mitophagy. WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of …

WebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of … WebJan 16, 2024 · We examined the sensitivity of 20 human cancer cell lines to X-rays, carbon ions, or cisplatin in a clonogenic survival assay (Figs 1,2).Details of the parameters …

WebOct 1, 2024 · The production of NAD + was elevated in the early stage of mild stimulation of cisplatin, while it was significantly consumed in the end. As one of the most important organelles in cell, mitochondria take charge of vital functions like energy production and ROS elimination. WebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of mitochondrial proteins and nucleotides. Mitochondria are key signaling hubs that fundamentally contribute to cancer development and progression.

WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis.

WebFeb 13, 2024 · Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferropt … earmor ptt baofengWebNational Center for Biotechnology Information ear mouth and footWebBackground: To study the protective effect of berberine (BBR) on cisplatin-induced acute kidney injury (AKI) and its effect on mitophagy. Methods: (I) Male C57BL/6 mice aged 6-8 weeks were randomly divided into control group (saline), cisplatin group (cisplatin), and cisplatin + BBR (5, 10 mg/kg) groups. csu wildlifeear mouth and throat medical toolWebSep 18, 2024 · NCBI Bookshelf ear mouth and neck painWebCisplatin is a widely used chemotherapeutic agent. Here we show that cisplatin induces apoptosis in renal collecting duct-derived cells (MDCK-C7 cells, resembling principal … ear mouth and nose doctorWebApr 22, 2024 · Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. ear mould in ear