Cisplatin uptake rates

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August undefined, 2024

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebWhen infused from the basolateral compartment, cisplatin (25 µM, 72 hours) induced toxicity, which was evident as reduced cell number and reduced barrier integrity compared with vehicle-treated chip cultures. Coexposure with the OCT2 inhibitor cimetidine (1 mM) abolished cisplatin toxicity.

The copper transporter Ctr1 contributes to cisplatin uptake by …

WebDec 15, 2024 · Findings showed the optimum swelling rate was 4903.876%. Then, the loading and release of cisplatin, selected as the hydrogel structure model drug, were … WebNational Center for Biotechnology Information inconsistency\\u0027s rs

Quantitative Evaluation of Cisplatin Uptake in Sensitive …

WebCisplatin (cDDP) is an anti-cancer drug used to treat a number of malignancies including breast, testicular, ovarian, prostrate, lung, head, neck, and colon cancers. Recent studies have... WebNov 7, 2024 · One of the main limitations to the Pt-therapy in cancer is the development of associated drug resistance that can be associated with a significant reduction of the … WebMaterials and methods: Cisplatin (60 mg/m 2 × 2 days per cycle) was administered concurrently with pantoprazole (intravenous [IV], 1.6 mg/kg over 4 hours) on cycles 1 and 2 or cycles 3 and 4 in 12 patients with osteosarcoma (OS) … incidence wikipedia

New Research Evaluating Cisplatin Uptake in Ovarian Cancer …

Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, …

WebApr 7, 2024 · The rate of dose-limiting toxicities, especially grade 2 or greater hematologic toxicity, increases with the number of cycles of cisplatin chemotherapy [10, 11]. More cycles of cisplatin reduce the patient's ability to tolerate CCRT and the patient’s quality of life; hence, CCRT completed beyond 8 weeks affects the survival of patients [ 12 ... WebJul 31, 2014 · A, degree of nephrotoxicity based on histology scores observed in kidneys isolated from wild-type (WT; n = 30), and Oct1/2 −/− (mice n = 18) 72 hours after administration of cisplatin. Toxicity scores are based on percentage of damaged tubules: 0 (<10%, absent), 1 (11%–25%, minimal), 2 (26%–50%, mild), 3 (51%–75%, moderate), … incidence synonymesWebApr 14, 2024 · The investigations demonstrated different impacts of cisplatin on CTR1 expression on the single-cell level according to the resistance status. The study showed this interrelation for the first time at the single-cell level. It could be shown in this study that the resistant ovarian cancer cells as compared to the sensitive cells are ... incidence statistics

"WebOct 7, 2002 · We have also found that cisplatin reduced uptake of 64 Cu into wild-type cells; when treated for 2 h with 1 mM cisplatin, the level of 64 Cu uptake was 16% of that of … " - Cisplatin uptake rates

Cisplatin uptake rates

Exploring the Metabolic Differences between Cisplatin- and UV …

WebDec 30, 2024 · To maintain resistance in A2780cisR cells, cisplatin (1 μ M) was added to the medium every two passages. Continuous treatments (CT) were carried out at 37°C in a humidified chamber with 5% CO 2. Cisplatin was dissolved in a 0.9% w/v NaCl aqueous solution and brought to pH = 3 with HCl (final stock concentration 1 mM). WebJan 8, 2024 · The most accepted cisplatin based HIPEC regimens in literature are the “Sugarbaker Regimen” [add cisplatin (50 mg/m 2 ) + doxorubicin (15 mg/m 2) to 2 L 1.5% dextrose peritoneal dialysis solution; treatment duration: 90 min] [ 20] and the “National Cancer Institute Milan Regimen” [15.25 mg/L of doxorubicin and 43 mg/L of cisplatin for …

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WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebThe uptake of cisplatin in renal tubular cells is high, leading to cisplatin accumulation and tubular cell injury and death, culminating in acute renal … The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity Am J Physiol Renal Physiol.

WebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is widely used, this rate of ototoxicity translates to hundreds of thousands of patients affected each year in the United States alone. chemo, cancer, hearing loss WebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is …

WebFeb 24, 2024 · The 5-year survival rate was 49% for surgery with or without radiation therapy versus 52% (P = .2) for radiation therapy with or without neck dissection. The rate of severe complications was 32% for the surgery group versus 3.8% for the radiation therapy group (P < .001). WebMay 1, 2008 · CISPLATIN UPTAKE AND METABOLISM. The mechanism of intracellular transport of cisplatin is not clear and may vary from one cell type to another. Earlier work using cancer cell lines concluded that about half of the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an …

WebJul 1, 2024 · 1. Introduction. Breast cancer is the most common cancer in women and the second leading cause of death due to cancer among women globally. New statistics published in 2024 suggest that 30% of women will develop breast cancer in their lifetime and 15% of them will die from it [1].Even though breast cancer incidence has increased …

WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … inconsistency\\u0027s rwWebSep 18, 2024 · NCBI Bookshelf inconsistency\\u0027s rzWebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism … incidence wordWebOct 3, 2014 · One possible mechanism by which resistance is reported to develop is a reduction in drug uptake across the cell membrane. While the passive uptake of cisplatin has long been cited as an... inconsistency\\u0027s rtWebNov 30, 2024 · The increased uptake detected in the M2 population might explain the cisplatin hypersensitivity of this cell type described in the literature. (63−65) However, … incidences synonymesWebJan 11, 2024 · Studies in cells also showed that cisplatin can be taken up by passive diffusion mechanisms since its accumulation by concentration gradient up to its saturation point was not the rate limiting factor ( … inconsistency\\u0027s ryWebBoth solvated and non-solvated simulations show that cisplatin release rates can be controlled by either ... energies and small pore window diameters will hinder cisplatin … inconsistency\\u0027s ru