WitrynaHERC5 loss drives CCL20 mRNA and protein over-expression and associates with regulatory T cell infiltration as measured by FOXP3 expression. Further, matched … Witryna14 kwi 2024 · Interferon-stimulated gene-15 (ISG15) is an interferon-induced protein with two ubiquitin-like (Ubl) domains linked by a short peptide chain, and the conjugated protein of the ISGylation system. Similar to ubiquitin and other Ubls, ISG15 is ligated to its target proteins with a series of E1, E2, and E3 enzymes known as Uba7, …
HERC5 is an IFN-induced HECT-type E3 protein ligase that ... - PNAS
Witryna11 gru 2015 · HERC5 plays a crucial role in HCC immune evasion and has clinical relevance as a reproducible prognostic marker for risk of tumor recurrence and … Witryna1 dzień temu · The EARLY-MYO-BC (NCT04510532) study aims to assess the cardiac impacts of pyrotinib for patients with HER2-positive breast cancer patients and determine whether pyrotinib combined with trastuzumab (Herceptin) is a reasonable dual HER2 blockade regimen with regard to cardiac safety. 1 Pyrotinib is a tyrosine kinase … frank hirth llc
Identification of HERC5 and its potential role in NSCLC progression ...
Witryna1 lis 2024 · ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free … Witryna1 lis 2024 · In vitro, HZ-6d significantly inhibited cell growth, suppressed cell migration, induced apoptosis in HCC cells. Further studies demonstrated the anti-cancer effect … WitrynaExpression of HERC5 (CEB1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. frank hirth tax