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WebExtracellular matrix (ECM) modifications in COPD. a) In the healthy lung, intact ECM consists of elastic fibres, proteoglycans and collagens and regulates the function of growth factors, as well as cell proliferation, differentiation, attachment, migration, shape and protein synthesis. b) In COPD, ECM is degraded by ECM enzymes, such as ... WebUnder hypoxia, H 2 S reduced the synthesis of collagen and elastin, ... Chen YH, Yao WZ, Geng B, et al. Endogenous hydrogen sulfide in patients with COPD. Chest. 2005;128(5):3205–3211. 43. Zhao H, Lu S, Chai J, et al. Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation. kevin mccarthy world health organization
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