WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … WebSummary of Review—This brief review provides a general overview and update of various signaling pathways in the development of apoptosis in ischemic lesions. Cerebral ischemia triggers two general pathways of apoptosis: the intrinsic pathway, originating from mitochondrial release of cytochrome c and associated stimulation of caspase-3; and
Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway ...
WebFeb 2, 2015 · The intrinsic apoptotic pathway engages caspases via members of the BCL-2 protein family and the mitochondria in reaction to severe cellular damage or stress. The extrinsic pathway activates caspases via cell-surface death receptors, which respond to cognate death ligands expressed on immune-effector cells. Webof apoptosis is terminated with the same final pathway as intrinsic stimuli does [1, 19, 27, 28]. Bid is the pro-apoptotic member of Bcl-2 family, exhibiting a common molecule be-tween intrinsic and extrinsic pathways of apoptosis. Caspase-8 causes the cleavage and myristoylation of cytoplasmic Bid protein ... times new roman os italic
Involvement of extrinsic and intrinsic apoptotic pathways …
WebJan 1, 2015 · Download Citation Apoptosis: The intrinsic pathway ... Request full-text PDF. To read the full-text of this research, you can request a copy directly from the author. Web3. Apoptosis signal pathway Apoptosis is triggered by multi-signal pathways and regulated by multi-complicated extrinsic and intrinsic ligands. The process of apoptosis … WebDec 19, 2024 · The induction of apoptosis by cathachunine occurred through an ROS-dependent mitochondria-mediated intrinsic pathway rather than an extrinsic pathway, and was regulated by the Bcl-2 protein family. times new roman pro