WebSelectins (L, E- and P-selectin) are a family of carbohydrate-binding cell adhesion molecules which play important roles in homing of lymphocytes, recruitment of leukocytes to sites of … WebThe E-selectin antagonists described herein may be used in methods for treating a disease or disorder associated with, mediated by, or exacerbated by E-selectin binding to an E …
Frontiers Targeting Selectins Mediated Biological …
WebJan 13, 2011 · Endothelial cell P-selectin, a member of the selectin family of cell adhesion molecules, 2 plays a key role in leukocyte recruitment as well as the adhesion of sickle RBCs to the endothelium. 3,4 Presynthesized P-selectin is stored in the Weibel-Palade bodies in endothelial cells and rapidly translocated to the cell surface in response to extracellular … There are three subsets of selectins: E-selectin (in endothelial cells)L-selectin (in leukocytes)P-selectin (in platelets and endothelial cells) L-selectin is the smallest of the vascular selectins, expressed on all granulocytes and monocytes and on most lymphocytes, can be found in most leukocytes. P-selectin, the … See more The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due … See more All three known members of the selectin family (L-, E-, and P-selectin) share a similar cassette structure: an N-terminal, calcium-dependent lectin domain, an epidermal growth factor (EGF)-like domain, a variable number of consensus repeat units (2, 6, and 9 for … See more Selectins have hinge domains, allowing them to undergo rapid conformational changes in the nanosecond range between ‘open’ and ‘closed’ conformations. Shear stress on the selectin molecule causes it to favor the ‘open’ conformation. In leukocyte rolling, … See more Selectins are involved in projects to treat osteoporosis, a disease that occurs when bone-creating cells called osteoblasts become too scarce. Osteoblasts develop from stem cells, and scientists hope to eventually be able to treat osteoporosis by adding stem cells to … See more The name selectin comes from the words "selected" and "lectins," which are a type of carbohydrate-recognizing protein. See more Selectins are involved in constitutive lymphocyte homing, and in chronic and acute inflammation processes, including post-ischemic inflammation in muscle, kidney and heart, … See more It is becoming evident that selectin may play a role in inflammation and progression of cancer. Tumor cells exploit the selectin-dependent mechanisms mediating cell … See more ladybridge primary school teachers
IJMS Free Full-Text Modulation of Selectin-Mediated Adhesion …
WebInformation and translations of P-Selectin in the most comprehensive dictionary definitions resource on the web. Login . The STANDS4 Network ... WebNational Center for Biotechnology Information WebE-selectin (also called CD62E) is expressed by endothelium, and P-selectin (CD62P) is produced by platelets and endothelium. L-selectin (CD62L) is found on leukocytes, including neutrophils, eosinophils, monocytes, and lymphocytes. All of these selectins mediate cell–cell interactions that are important in the recruitment of leukocytes. ladybridge roundabout