Phosphomevalonate
Web216151 Ensembl ENSG00000099821 ENSMUSG00000020329 UniProt O00411 Q8BKF1 RefSeq (mRNA) NM_005035 NM_172551 RefSeq (protein) NP_005026 NP_766139 NP_001394721 NP_001394722 NP_001394723 NP_001394724 NP_001394725 NP_001394726 NP_001394727 NP_001394728 Location (UCSC) Chr 19: 0.62 – 0.63 Mb … WebImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Phosphomevalonate kinase antibody (ab65806) Paraffin embedded rat skeletal muscle tissue stained for Phosphomevalonate kinase using ab65806 at 1 µg/ml in immunohistochemical analysis.
Phosphomevalonate
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WebAccession GO:0004631 Name phosphomevalonate kinase activity Ontology molecular_function Synonyms 5-phosphomevalonate kinase activity, ATP:(R)-5-phosphomevalonate phosphotransferase activity, ATP:5-phosphomevalonate phosphotransferase activity, mevalonate phosphate kinase activity, mevalonate-5 … WebSep 17, 2024 · The decarboxylase [i.e., phosphomevalonate decarboxylase (PMD)] was recently identified from a halophilic archaeon, Haloferax volcanii ( 8 ), and a Chloroflexi bacterium, Roseiflexus castenholzii ( 9 ). The discovery substantiated the existence of the proposed modified pathway in these organisms.
WebPhosphomevalonate eluted at ∼0.35 m salt and contained <1% nucleotide, <5% pyruvate, and <1% P-enolpyruvate. The purified phosphomevalonate was loaded onto a 3-ml Fast-Q … WebNov 2, 2024 · We identified phosphomevalonate kinase (PMVK), a key mevalonate pathway enzyme, and sterol regulatory element-binding factor 2 (SREBF2), the master cholesterol biosynthesis regulator, as direct miR‑874 targets.
WebJan 1, 2024 · The 5-phosphomevalonate kinase(PMK) is a key enzyme in mevalonate(MVA) pathway which reversibly catalyzes the phosphorylation of mevalonate 5-phosphate(MVAP) to form mevalonate-5-diphosphate(MVAPP ... WebThe mevalonate pathway (MP) also known as the isoprenoid pathway or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway is an anabolic pathway providing …
WebNov 2, 2024 · phosphomevalonate kinase (PMVK), a key mevalonate pathway enzyme, and sterol regulatory element‑binding factor 2 (SREBF2), the master cholesterol biosynthesis regulator , as direct miR-874 targets.
WebPhosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13-1q22-23 and present a genomic map indicating that the gene spans more than 8.4 kb in the human … grace darling bbc bitesizeWebJan 27, 2014 · We have characterized the kinetic parameters of phosphomevalonate kinase (PMK, EC 2.7.4.2) from Saccharomyces cerevisiae, a previously unstudied enzyme. An E. coli codon-optimized version of the S. cerevisiae gene was cloned into pET-52b+, then the C-terminal 6X His-tagged protein was expressed in E. coli BL21(DE3) and purified on a Ni 2+ … grace darling school newbigginWebNov 2, 2024 · We identified phosphomevalonate kinase (PMVK), a key mevalonate pathway enzyme, and sterol regulatory element-binding factor 2 (SREBF2), the master cholesterol … grace darling key stage 1Web(R)-5-Diphosphomevalonate C6H10O10P2-4 CID 24916915 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... grace darling lighthouse keeperWebnoun. phos· pho· nate ˈfäs-fə-ˌnāt. : a salt or ester of a phosphonic acid. grace darling tim vicaryWebPhosphonates are one of the three sources of phosphate intake in biological cells. [citation needed] The other two are inorganic phosphate and organophosphates. The naturally … chilled lobster and shrimp appetizerWebDec 10, 2013 · The classical mevalonate pathway is found in most eukaryotes, including humans; statin drugs are used to inhibit this pathway to treat those with high cholesterol and reduce the risk of heart disease. The second pathway does not use the compound mevalonate and is found in many, but not all, bacteria as well as the chloroplasts of plants. grace darling north star