Pttg1 and p53

Author: tmbi

August undefined, 2024

WebObjective To analyze the expression of pituitary tumor transforming gene 1 (PTTG1) in hepatocellular carcinoma (HCC) and its clinical prognostic implication. ... p53 signaling pathway and human T-lymphotropic virus (HTLV) infection. PTTG1 and its co-expressed genes were mutated to some extent in HCC, and significantly shortened OS and DFS in ... WebDec 25, 2024 · Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. ... protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor …

Transcriptional targets for pituitary tumor-transforming …

WebJul 16, 2010 · Significantly, the PTTG1-induced senescence is p53-dependent and telomerase-independent, which is distinctively different from that of replicative senescence. The mechanism of PTTG1-induced senescence was also analyzed. Consistent with its role in regulating sister-chromatid separation, overexpression of PTTG1 inhibited the … WebJun 29, 2024 · Background Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer (BLCA) remains obscure. This research is intended to analyze the aberrant expression and clinical significance of PTTG1 in BLCA, explore the relationship between … mike inez acoustic bass

[Pituitary tumor transforming gene 1 (PTTG1) is highly ... - PubMed

WebPituitary tumor-transforming gene 1 protein (PTTG1) immunostaining and P53 expression. Source publication Upregulation of PTTG1 is associated with poor prognosis in prostate cancer WebApr 20, 2006 · To this end, we examined the effect of PTTG1 depletion on endogenous levels of p53 and p21. p21 is one of many genes to be induced by p53 and functions as a cyclin-dependent kinase inhibitor, which induces in cell-cycle arrest at G1 phase. 34 p53 level was not markedly affected by PTTG1 depletion, but p21 level was increased in a viral … WebOct 1, 2015 · For example, PTTG1 (securin) specifically bound to p53 and interfered with DNA binding of p53, significantly reducing the transcriptional activity of p53 on p53-specific promoters . In this study, we present evidence that PTTG1, behaving as a miR-329, miR-300, miR-381 and miR-655 target gene, acts to mediate cell transformation and tumor formation. mike in fools and horses

Transcriptional targets for pituitary tumor-transforming …

Overexpression of the pituitary tumor transforming gene induces p53 …

WebOn the other hand, PTTG1 is a p53 target gene, and p53 inhibits NF-Y binding to the PTTG1 promoter and thus inhibits PTTG expression [226, 227]. Alternatively, p53 inhibits PTTG expression by ... WebAug 12, 2015 · Pituitary tumor-transforming gene-1 (PTTG1) was isolated from rat pituitary tumor cells in 1997 . As a vertebrate ... b Signaling network analysis of 662 differentially expressed genes revealed a network involve p53 and CTNNB1. c PTTG1 regulates DKK1 expression. HCT116 cells were transfected with pcDNA3.1 and negative control siRNA … mike infanger insurance idaho falls mike in croatian

"WebSep 26, 2024 · pituitary tumor-transforming gene 1 protein-interacting protein, PTTG-binding factor, pituitary tumor-transforming gene protein-binding factor GeneRIFs: Gene References Into Functions protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are … " - Pttg1 and p53

Pttg1 and p53

WebJul 8, 2004 · PTTG upregulates expression of p53 in HEK293 and MCF-7 cells. To determine the relationship between PTTG and p53, we first determined the effect of overexpression of PTTG on p53 expression. For this purpose, we used three different cell lines. Two of these HEK293, which is a human embryonic kidney cell line, and MCF-7, which is a human … WebJul 28, 2008 · Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases. ... PTTG1 inhibits p53 ...

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WebSep 23, 2002 · a, Schematic diagram of human p53 and the shorter PTTG1-interacting TP53 cDNA. The structure of p53 is shown, including the transactivation domain (TA), DNA-binding domain (DB), tetramerization ... WebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. ... PTTG1 staining was one of the histological features (numerous mitoses, high Ki-67 index, and nuclear labelling of PTTG1 and P53) distinguishing aggressive–invasive PRL tumors from those behaving less aggressively ...

WebJul 28, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) has been identified as an oncogene and is overexpressed in many tumor types. However, the role of PTTG1 in glioblastoma (GBM) has not been well characterized, especially in relation to angiogenesis, migration, and invasion. ... VEGF, MMP2, MMP9, MMP14, p53, p21 and cyclin D1. Pearson … WebPTTG1 has been shown to interact with: DNAJA1, Ku70; P53, PTTG1IP, and; RPS10. Regulation. During Mitosis CDK1 phosphorylate PTTG1 at Ser-165. PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase …

WebJul 16, 2010 · To gain insight into the molecular basis of PTTG1-induced growth arrest and senescence in normal fibroblasts, we examined the expression pattern of several key cell cycle regulators that are involved in senescence using immunoblotting analysis.In IMR90 cells, PTTG1 overexpression consistently induced p53 expression and inhibited Rb protein … WebAug 23, 2024 · The p53 Signaling PCR array includes 24 genes involved in cell cycle regulation. Results indicate that nine of these genes were significantly altered in FLT samples. ... PTTG1 (Pituitary tumor-transforming gene 1) regulates the cell cycle by inducing cyclin D3 and repressing p21 expression .

Web[Pituitary tumor transforming gene 1 (PTTG1) is highly expressed and associated with poor prognosis in patients with hepatocellular carcinoma]. ... PTTG1 is overexpressed in nodular melanoma, and contributes to tumor progression by causing aneuploidy or by modulating p53-function; PTTG1 gene expression is mediated by Sp1 and is indirectly down ...

WebMar 21, 2024 · Pituitary tumor-transforming gene 1 protein (PTTG1_HUMAN) PTTG1 protein (Q2VPE7_HUMAN) cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA (Q6IAL9_HUMAN) ... Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by … mike ingalls wcauWebOct 6, 2015 · Notably, some of the genes found to strongly correlate with PTTG1 expression in this study, including CDK1, CCNB1, CCNB2 and BIRC5 are known to be inhibited downstream of p53 [68–70]; p53-mediated regulation of gene expression down stream of PTTG1 could be a focus of future studies. However, we found no correlation between … new westminster property tax due datesWebFIGURE 3 p53 is required of PTTG1-induced senescence in normal cells. A, IMR-90 cells were infected with adenoviruses carrying GFP or PTTG1. Cell extracts were prepared 4 days after infection and then analyzed by … mike influencerWebJul 24, 2024 · PTTG1 may also block p53 and regulate DNA repair mechanisms and apoptosis (Hornig et al., 2002). Our group has assessed a cohort of HTLV-1 asymptomatic carriers with the goal of finding clinical and molecular aspects related to ATL progression ( Sanabani et al., 2012 ; Pessoa et al., 2014 ; de Souza et al., 2024 ). mike in convoyWebAs PTTG1 (pituitary tumor transforming gene) abundance correlates with adverse outcomes in cancer treatment, we determined mechanisms underlying this observation by assessing the role of PTTG1 in regulating cell response to anti-neoplastic drugs. ... Binding of Sp1, p53 and p300 to the p21 promoter was enhanced in PTTG1(-/-) cells after ... mike ingleby realty one groupWebFeb 24, 2024 · Pituitary tumor-transforming gene-1 (PTTG1), one type of DNA repair-related gene, has been reported to be dysregulated in several tumors and serve as a tumor promotor. Previously, the oncogenic roles of PTTG1 were also reported in lung adenocarcinoma (LUAD). However, the prognostic values of PTTG1 in LUAD and the … mike infirnity credit cardWebFeb 25, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. ... Moreover, the UBE2C-mediated P53 ubiquitination could be a potential target in LIHC … mike inglis cyclist