WebOct 6, 2016 · A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo proteins … WebRab7 effector Rab7-interacting lysosomal protein (RILP) in association with the oxysterol-binding protein ORP1L, forming the tripartite motor complex. ORP1L sense cholesterol levels in LEs. Under high cholesterol conditions, LEs accumulate at the microtubule minus end as the result of dynein motor activity.

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WebThus, Rab7 could be considered a negative regulator of many pro-survival signals from the cell surface. In fact, the Rab7 effector Rabring7 is an E3 ligase involved in EGFR … Websecrete numerous effector proteins, including SifA, through a specialized type III secretion system to hijack the host endosomal system and generate the Salmonella-containing … journal of cybernetics and systems

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WebChronic alcohol consumption retards lipophagy, which contributes to the pathogenesis of liver steatosis. Lipophagy-related Rab7 has been presumed as a crucial regulator in the … WebJun 24, 2024 · Secretion is a fundamental process in all living organisms. Using conventional secretion pathways, many plant pathogens release effectors into the host … WebRab7 is also involved in the maturation of late autophagic vacuoles. Among Rab7 effectors are Rab-interacting lysosome protein (RILP) that controls late endosomal and lysosomal … how to lower data usage on android